Paracetamol
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Pharmaceutical Chemicals
Paracetamol is mainly used for fever, headache and relief of mild and moderate pain caused by cold, such as joint pain, muscle pain, neuralgia, migraine, dysmenorrhea, cancer pain and postoperative analgesia. Paracetamol can also be used in patients who are too sensitive to aspirin, intolerant or unsuitable for aspirin use: such as chickenpox, hemophilia and other bleeding disorders (including patients receiving anticoagulant therapy), and patients with mild peptic ulcer and gastritis.
| Traits | Colorless crystalline powder |
|
TEST ITEMS |
STANDARD |
RESULTS |
|
Character |
Should be white crystal or crystalline powder, odorless. Freely soluble in hot water or ethanol, soluble in acetone, slightly soluble in water. |
White crystal, odorless. Freely soluble in ethanol, soluble in acetone, slightly soluble in water. |
|
Melting point |
168~172℃ |
170.0~170.7℃ |
|
Acidity |
PH5.5~6.5 |
5.9 |
|
Clarity and color of ethanol solution |
Clear, colorless or not deeper than the control solution |
Clear, colorless |
|
Chloride |
≤0.01% |
＜0.01% |
|
Sulfate |
≤0.02% |
＜0.02% |
|
Related substance |
Para-aminophenol should not exceed 0.005% |
0.0002% |
| Related substance |
Other single impurities shall not exceed 0.1% |
0.017% |
| Related substance |
The sum of other impurities shall not exceed 0.5% |
0.027% |
|
P-chlorophenacetamide |
≤0.005% |
ND(＜LOD) |
|
Loss on drying |
≤0.5% |
0.10% |
|
Residue on ignition |
≤0.1% |
0.05% |
|
Heavy metal |
≤0.001% |
＜0.001 |
|
Content (by dry product) |
98.0~102.0% |
99.6% |
|
Conclusion |
Qualified |
Qualified |
It works by acting on the hypothalamic temperature regulation center, dilating peripheral blood vessels, increasing blood flow and sweating, thereby achieving a fever-reducing effect.
It primarily works by inhibiting the synthesis of prostaglandins, reducing the sensitivity of peripheral nerve endings, thereby relieving mild to moderate pain.
